- Jacksonville Jaguars: Trevor Lawrence, QB, Clemson
- New York Jets: Justin Fields, QB, Ohio St
- San Francisco 49ers (from Dolphins via Texans): Zach Wilson, QB, BYU
- Atlanta Falcons: Trey Lance, QB, North Dakota State
- Cincinnati Bengals: Ja’Marr Chase, WR, LSU
- Miami Dolphins (from Philadelphia Eagles): DeVonta Smith, WR, Alabama
- Detroit Lions: Penei Sewell, OT, Oregon
- Carolina Panthers: Kyle Pitts, TE, Florida
- Denver Broncos: Patrick Surtain II, CB, Alabama
- Dallas Cowboys: Jaycee Horn, CB, South Carolina
- New York Giants: Micah Parsons, LB, Penn St
- Philadelphia Eagles (from Dolphins via 49ers): Jaylen Waddle, WR, Alabama
- Los Angeles Chargers: Rashawn Slater, OT, Northwestern
- Minnesota Vikings: Alijah Vera-Tucker, OG, USC
- New England Patriots: Jaelan Phillips, Edge, Miami
- Arizona Cardinals: Greg Newsome, CB, Northwestern
- Las Vegas Raiders: Jeremiah Owusu-Koramoah, LB, Notre Dame
- Miami Dolphins: Najee Harris, RB, Alabama
- Washington Football Team: Mac Jones, QB, Alabama
- Chicago Bears: Christian Darrisaw, OT, Virginia Tech
- Indianapolis Colts: Gregory Rousseau, Edge, Miami
- Tennessee Titans: Elijah Moore, WR, Ole Miss
- New York Jets (from Seattle Seahawks): Teven Jenkins, OL, Oklahoma St
- Pittsburgh Steelers: Travis Ettiene, Rashod Bateman, WR, Minnesota
- Jacksonville Jaguars (from Los Angeles Rams): Travis Ettiene, RB, Clemson
- Cleveland Browns: Zaven Collins, LB, Tulsa
- Baltimore Ravens: Trevon Moehrig, S, TCU
- New Orleans Saints: Tyson Campbell, CB, Georgia
- Green Bay Packers: Kwity Paye, Edge, Michigan
- Buffalo Bills: Azeez Ojulari, OLB, Georgia
- Baltimore Ravens (from Kansas City Chiefs): Terrace Marshall Jr., WR, LSU
- Tampa Bay Buccaneers: Christian Barmore, DT, Alabama